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And then you get into antagonistic pleiotropy

For example, the efficacy of several small molecular targets has been well demonstrated in animal models, such as mGluR5 inhibitors, OT, Memantine, and mTOR inhibitors, but is still unsatisfactory in clinical trials

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And if you look at the data in some of their in some of their tables, youll see that men that spent only 11 minutes in the sauna, even if it was four to seven times a week they only had like an 8 percent reduction in cardiovascular related mortality compared to like a 50 percent reduction