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And the compound has a short-term safety profile, at least in qualified sourcing conditions, that warrants continued investigation rather than dismissal

Disease Management and Clinical Outcomes, 1(4), 136-141

Lengthy treatment protocols, an inability to afford expensive interventions (especially assisted reproductive techniques), and financial difficulties incurred through treatment can add to the burden of stress

A 2-step model has been proposed: the first step of ATXN3 self-assembly, common to WT and polyQ-expanded ATXN3, is centered on the N-terminal Josephin domain