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In another randomized clinical trial, CB-839 did not enhance the therapeutic efficacy of cabozantinib in metastatic RCC (Tannir et al., 2021)

This coordinated process leads to the selective engulfment of damaged mitochondria into autophagosomes, which are then delivered to lysosomes for degradation ( In contrast, receptor-mediated mitophagy operates through a ubiquitin-independent mechanism