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Graphical Abstract Similar content being viewed by others Introduction Premature ovarian insufficiency (POI), whether idiopathic or resulting from chemotherapy-induced ovarian failure (CIOF), poses a significant threat to the reproductive and endocrine health of women globally [1, 2]

Recent research has elucidated several mechanisms underlying this association, including disruption of the epithelial barrier, production of carcinogenic substances (e.g., nitrosamines and acetaldehyde), and induction of chronic inflammation (Liao et al., 2020)

it needs high-level care and structural repair

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