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Signs of immune cell activation, including increased numbers of white blood cells, monocytes, memory T cells (CD4 + CD45RA + ), activated T cells (e.g., CD7 + CD25+ and CD2 + HLADR + ), and B cells (CD19 + , CD20 + , and CD21 + ), coupled with an increased CD4 + /CD8+ ratio [24,25,26,27], were detected in various study populations of IMDD patients

The folding of polypeptides into their functional forms is the topic of the next section.

Am J Respir Crit Care Med 167 : 395399 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP 2009 Innate immunity against bacterial infection following hyperoxia exposure is impaired in nrf2-deficient mice

When a persons immune system is exposed to bacteria or a virus, it learns how to combat the infection and creates a memory to be more effective at tackling it the next time we get sick