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SAD patients showed enrichment of novel genera Anaeromassilibacillus and Gordonibacter , whereas Anaeromassilibacillus was linked to autism spectrum disordera condition with high SAD comorbidity ( 3.3.4 MGBA alterations and pathophysiological mechanisms in anxiety Rodent models of anxiety disorders provide causal evidence that stress exposure disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance (Tyagi et al., 2025) and humid heat environment stress models (Weng et al., 2024) Enrichment of the phylum Proteobacteria was observed across multiple stress paradigms (Jia et al., 2024

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Despite rapid advances in the design of Erastin analogs and derivatives, the fundamental problem of on-target toxicity remains unresolved