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Melatonin, sleep, and shift work adaptation

DOI: 10.1038/nrn1583 Schwartz M et al (1990): Oral nifedipine in the treatment of hypertensive urgency: cerebrovascular accident following a single dose

Hall DE, MacGregor KB, Nijsse J, Bown AW (2002) Footsteps from insect larvae damage leaf surfaces and initiate rapid responses

What this means for clinical research: There is less room for protocol errors, recruitment delays, or weak endpoints execution quality in Phases IIIII is becoming a primary determinant of asset value