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Despite its translational advantages, clinical application of DFP and other iron chelators is not without risks: neutropenia remains a serious adverse event frequently observed in patients receiving iron chelation therapy (230)

This dissociation underscores the principle that biomarker improvement does not equate to immediate, measurable clinical benefit, suggesting a potential delay between biological effect and functional stabilization (47)

An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses

Journal of hazardous materials