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To stop signal transduction, Kdm2a/b competes with TCF/LEF for -catenin binding and removes methyl markers from -catenin, which is subsequently degraded via ubiquitination

[14] Vessels studied from several archaeological sites in Israel (dating to around 5,000, 3,000 and 2,500 years ago), which were believed to have contained alcoholic beverages (beer and mead), were found to contain yeast colonies that had survived over the millennia, providing the first direct biological evidence of yeast use in early cultures

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