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[11] PubChem NNMTi (5-Amino-1-methylquinolinium iodide compound listing).
Effects on specific populations including the elderly, those with metabolic disease, and women have not been specifically investigated
In asymptomatic patients with risk factors (see Table 1: Patient Risk Factors Associated with B 12 Deficiency below) consider supplementation in lieu of testing
For individuals requiring supplementation due to confirmed deficiency or malabsorption, therapeutic doses vary considerably depending on the underlying cause: Dietary deficiency : 50150 micrograms daily orally, or cyanocobalamin tablets as prescribed Pernicious anaemia : Initially hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks, then maintenance injections every two to three months [3] Neurological involvement : More intensive regimens may be required, with hydroxocobalamin injections on alternate days until symptom improvement [3] NICE guidance emphasises that supplementation should be evidence-based rather than speculative
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